Table_2_Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han Chinese.pdf

Tetraspanin 2 (TSPAN2) belongs to the tetraspanin superfamily. Previous studies have identified significant associations of the TSPAN2 single nucleotide polymorphisms (SNPs) rs12134493 and rs2078371 with migraine in Western populations; however, these associations need to be confirmed in the Chinese Han population. In addition, we carried out further studies to see whether TSPAN2 is associated with susceptibility to migraine to provide new clinical evidence. A case-control study (425 patients with migraine and 425 healthy controls) in a Chinese Han population was performed to evaluate the associations between migraine and TSPAN2 via a genotype-phenotype analysis between TSPAN2 and clinical symptoms. The SNP rs2078371 was found to be significantly associated with migraines especially in migraines without aura (MO) and in female patients. Meta-analysis revealed that the A allele of rs12134493 was significantly associated with migraines (OR = 1.14, P = 0.0001). Our findings suggested that TSPAN2 is a potential susceptibility factor for migraines. To confirm our results, a large-scale Chinese Han population study should be conducted. Considering that these two SNPs have not been definitively shown to affect TSPAN2 or to regulate nearby genes in this genomic region, the biological function and molecular mechanism of TSPAN2 in migraine should be further explored.

四跨蛋白2（TSPAN2）隶属于四跨蛋白超家族。既往研究已揭示TSPAN2单核苷酸多态性（SNPs）rs12134493和rs2078371与西方人群中偏头痛的显著关联；然而，这些关联性尚需在中国汉族人群中得到验证。此外，本研究进一步探究TSPAN2与偏头痛的易感性关联，以提供新的临床证据。针对中国汉族人群进行了一项病例对照研究（425名偏头痛患者与425名健康对照者），通过TSPAN2与临床症状之间的基因型-表型分析，评估了偏头痛与TSPAN2之间的关联。研究发现，SNP rs2078371与偏头痛，尤其是无先兆偏头痛（MO）和女性患者显著相关。荟萃分析显示，rs12134493的A等位基因与偏头痛显著相关（OR = 1.14，P = 0.0001）。我们的研究结果表明，TSPAN2可能是偏头痛的潜在易感因素。为了证实我们的研究结果，应在中国汉族人群中开展大规模的研究。鉴于这两个SNPs尚未被明确证实影响TSPAN2或调节该基因组区域的邻近基因，因此需要进一步探讨TSPAN2在偏头痛中的生物学功能和分子机制。