General activity in an square arena.

Locomotor and behavioral parameters registered on pnd 71 of male and female animals administered with vehicle (Vh) or increasing doses of THC (2.5, 5 and 10 mg/kg) from pnd 28 to 45, and with saline (Sal) or MDMA (10 mg/kg twice daily) every 5 day from pnd 30 to pnd 45. The data are expressed as the mean ± SEM. In parenthesis, the number of animals per experimental group. ANOVA (P<0.05), asignificant overall effect of sex; bsignificant overall effect of THC; dsignificant effect of MDMA in vehicle-treated animals.