G alpha (12) binds BTK

G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein subunit alpha-12 (GNA12) can bind directly to the PH domain of the non-receptor Tyrosine-protein kinase BTK (BTK) in vitro and in vivo. This binding results in the activation of BTK. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.

G蛋白偶联受体（G-Protein Coupled Receptors，GPCR）能够感知细胞外信号并激活不同的鸟苷酸结合蛋白。在激活过程中，鸟苷酸结合蛋白亚基α-12（GNA12）能够在体外和体内直接与无受体酪氨酸蛋白激酶BTK（BTK）的PH结构域结合。这种结合导致BTK的激活。在生理学上，BTK在B淋巴细胞的发育、分化和信号传导中发挥着关键作用。