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Transcriptomic changes in TP53-mutated B-cell precursor acute lymphoblastic leukemia cell lines

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NIAID Data Ecosystem2026-05-10 收录
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TP53 mutations are associated with poor prognoses in B-cell precursor acute lymphoblastic leukemia, indicating that specific p53 downstream genes may contribute to resistance to various chemotherapeutic agents. To elucidate these mechanisms, RNA-seq data from eleven TP53 gene knockout sublines and parental cell lines were obtained and analyzed.

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2025-10-25
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