Rosmarinic acid changes the hippocampal transcriptome in 3 × Tg mice.

Rosmarinic acid (RA), has been regarded as a capable component of preventing AD since it suppresses aggregation of amyloid β (Aβ). Despite the understanding of the association of Aβ suppression with RA, little is known regarding the effect of RA on tau phosphorylation and cognitive dysfunction. Therefore, we investigated the influence of RA on the hippocampal transcriptome, and elucidated the mechanism by which RA prevents AD. In order to clarify the effect of RA, the gene expression of the hippocampus of male 3 × Tg mice who ingested RA for 8 months was compared with non-ingested mice of the same age.