Activated FGFR2 phosphorylates SHC1

The p46 and p53 isoforms of SHC1 have been shown to be phosphorylated upon FGF stimulation. Three consensus RTK phosphoryation sites are present in SHC1, although phosphorylation of these specific tyrosine residues has not been explicitly demonstrated in response to FGF stimulation. In contrast, the p66 isoform of SHC1 does not appear to undergo FGF-dependent phosphorylation.

SHC1蛋白的p46和p53亚型在FGF刺激下已被证实现磷酸化。SHC1蛋白中存在三个RTK磷酸化位点的一致序列，尽管这些特定的酪氨酸残基在FGF刺激下的磷酸化尚未得到明确证实。相反，SHC1蛋白的p66亚型似乎不经历FGF依赖的磷酸化。