Vilsmeier−Haack Reaction of 1-Cyclopropyl-2-arylethanones
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https://figshare.com/articles/dataset/Vilsmeier_Haack_Reaction_of_1_Cyclopropyl_2_arylethanones/2901727
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资源简介：
A convenient and efficient method to synthesize 3-(2-chloroethyl)-5-aryl-4H-pyran-4-ones 2 and 2-chloro-3-(2-chloroethyl)-1-naphthaldehydes 3 in moderate to good yields was developed via the Vilsmeier−Haack reaction of readily available 1-cyclopropyl-2-arylethanones 1 at different temperature. This reaction proceeds via sequential enolization, ring opening, haloformylation, and intramolecular nucleophilic cyclization or Friedel−Crafts alkylation reactions to produce 2 or 3.
创建时间：
2016-02-27
