Creld1-deficient CD4+ T cells under homeostatic condition and CD3/CD28 stimulation. Creld1-deficient CD4+ T cells under homeostatic condition and CD3/CD28 stimulation

Transciptome profiling of sorted naive CD4+ T cells from control or Creld1 conditional KO mice (CD4-Cre) both directly ex vivo and with or without stimulation with anti-CD3/anti-CD28 antibodies to study the impact of Creld1 on T cell biology Overall design: Conventional naïve CD4+ T cells from either Creld1 conditional knockout (CD4-Cre) or control mice as well as from eight-hour ex vivo cultures with or without T cell receptor stimulation by anti-CD3/anti-CD28 (n=3 / group)