Yeast 20S proteasome in complex with the covalently bound inhibitor b-lactone (2R,3S)-3-isopropyl-4-oxo-2-oxetane-carboxylate (IOC)

Yeast 20S proteasome in complex with the covalently bound inhibitor b-lactone (2R,3S)-3-isopropyl-4-oxo-2-oxetane-carboxylate (IOC) Descriptor: (2 {R},3 {S})-3-methanoyl-4-methyl-2-hydroxy-pentanoic acid, 20S proteasome, BJ4_G0020160.mRNA.1.CDS.1, ... Authors: Shi, Y.M, Hirschmann, M, Shi, Y.N, Shabbir, A, Abebew, D, Tobias, N.J, Gruen, P, Crames, J.J, Poeschel, L, Kuttenlochner, W, Richter, C, Herrmann, J, Mueller, R, Thanwisai, A, Pidot, S.J, Stinear, T.P, Groll, M, Kim, Y, Bode, H. Deposit date: 2021-03-30 Release date: 2022-04-13 Last modified: 2025-10-01 Method: X-RAY DIFFRACTION (3 Å) Cite: Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria. Nat.Chem., 14, 2022

本数据集为酵母20S蛋白酶体（20S proteasome）与共价结合抑制剂β-内酯（β-lactone）(2R,3S)-3-异丙基-4-氧代-2-氧杂环丁烷羧酸酯（IOC）形成的复合物。数据集描述项包括：(2R,3S)-3-甲酰基-4-甲基-2-羟基戊酸、20S蛋白酶体、BJ4_G0020160.mRNA.1.CDS.1等。作者：Shi, Y.M、Hirschmann, M、Shi, Y.N、Shabbir, A、Abebew, D、Tobias, N.J、Gruen, P、Crames, J.J、Poeschel, L、Kuttenlochner, W、Richter, C、Herrmann, J、Mueller, R、Thanwisai, A、Pidot, S.J、Stinear, T.P、Groll, M、Kim, Y、Bode, H。存档日期：2021年3月30日；发布日期：2022年4月13日；最后修改日期：2025年10月1日。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率3 Å。引用文献：《Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria》，《自然-化学》（Nat.Chem.），第14卷，2022年。