Real world data of 5-aminolevulinic acid-mediated photodynamic therapy for Bowen’s disease: A 10-year retrospective study in China (2010-2020)

Photodynamic therapy (PDT) is an alternative treatment for Bowen’s disease (BD). However, reported data on 5-aminolevulinic acid-mediated PDT (ALA-PDT) with red light irradiation are limited and the long-term efficacy remains to be determined, especially in dark-skinned populations. The present study aimed to review routine clinical practice in the field of BD treatment with ALA-PDT over an extended study period, calculate the overall clearance rate, and try to evaluate factors that might affect the effectiveness of therapy in a real-world setting.