Rh(I)-Catalyzed Allenic Pauson–Khand Reaction to Access the Thapsigargin Core: Influence of Furan and Allenyl Chloroacetate Groups on Enantioselectivity
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https://figshare.com/articles/dataset/Rh_I_-Catalyzed_Allenic_Pauson_Khand_Reaction_to_Access_the_Thapsigargin_Core_Influence_of_Furan_and_Allenyl_Chloroacetate_Groups_on_Enantioselectivity/19074203
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资源简介：
Thapsigargin
(Tg) is a potent SERCA pump inhibitor with the potential
to treat cancer and COVID-19. We have extended the scope of the asymmetric
allenic Pauson–Khand reaction to furan-tethered allene-ynes,
a stereoconvergent transformation affording the 5,7,5-ring system
of Tg in good yields and high enantioselectivity. Computational studies
of the oxidative cyclization step show that the furan and chloroacetate
groups contribute to this high selectivity.
创建时间：
2022-01-26
