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Hf(OTf)<sub>4</sub>‑Catalyzed 1,6-Conjugate Addition of 2‑Alkyl-azaarenes to <i>para</i>-Quinone Methides

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NIAID Data Ecosystem2026-03-12 收录
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Herein we reported a Hf­(OTf)4-catalyzed carbon–carbon bond formation reaction between 2-alkyl-azaarenes and para-quinone methides (p-QMs). This 1,6-conjugate addition protocol offered rapid access to a large array of triarylethane products in good yields. The catalyst loading could be reduced to 1 mol %. Studies pertinent to scale-up reaction and product derivatization were also presented.

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2021-02-01
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