小鼠类淋巴系统的MRI数据集: DCE-MRI和定量脑血容积MRI

类淋巴系统通过促使脑脊液（CSF）沿着整个大脑血管周围空间流动以促进废物的清除。血管舒缩，即血管的缓慢运动（0.1-0.3 Hz），已被发现是血管周围清除的动力之一，但可宏观反映脑血管更加缓慢运动的脑血容积（CBV）是否对淋巴功能有影响尚不清楚。
MRI是一套功能强大的成像工具，并为当前类淋巴系统调节机制的探究提供了关键测量技术。本研究我们使用了多模态小鼠MRI技术，包括DCE-MRI（用于估计类淋巴系统功能和T1 mapping）和定量脑血容积 MRI（用于定量化CBV）。为便于应用，该数据集提供了上述两种MRI技术的原始数据。数据集包括六种不同状态下（清醒、右美托咪定、异氟烷、异氟烷/右美托咪定、氯胺酮/噻嗪和咖啡因）丰富的小鼠MRI数据，用于研究类淋巴系统内流、CBV和CSF体积之间的关系。

The glymphatic system promotes waste clearance by driving cerebrospinal fluid (CSF) flow along the perivascular spaces throughout the brain. Vasomotion, i.e., the slow rhythmic movement of blood vessels (0.1–0.3 Hz), has been identified as one of the driving forces for perivascular clearance. However, whether cerebral blood volume (CBV), which macroscopically reflects the even slower movement of cerebral blood vessels, affects glymphatic function remains unclear.
Magnetic Resonance Imaging (MRI) is a powerful imaging tool that provides critical measurement technologies for current studies on the regulatory mechanisms of the glymphatic system. In this study, we utilized multimodal mouse MRI techniques, including dynamic contrast-enhanced MRI (DCE-MRI, used to estimate glymphatic function and perform T1 mapping) and quantitative cerebral blood volume MRI (for CBV quantification). To facilitate research applications, this dataset provides raw data from both of the above-mentioned MRI techniques.
The dataset contains abundant mouse MRI data under six different conditions: awake, dexmedetomidine-treated, isoflurane-anesthetized, isoflurane combined with dexmedetomidine, ketamine/xylazine-anesthetized, and caffeine-treated. These data are designed for investigating the correlations among glymphatic system influx, CBV, and CSF volume.

搜集汇总

背景与挑战

背景概述

该数据集包含小鼠类淋巴系统的DCE-MRI和定量脑血容积MRI数据，旨在研究类淋巴流入、脑血容积和脑脊液体积之间的关系。数据集提供了六种不同条件下的小鼠MRI原始数据，适用于类淋巴调节机制的研究。