Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and cholesterol-hemisuccinate
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Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and cholesterol-hemisuccinate Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Llama-derived nanobody NB64, ... Authors: Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C. Deposit date: 2019-05-27 Release date: 2019-10-02 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat.Chem.Biol., 15, 2019
Patched-1 (PTCH1) 胞外域与纳米抗体（nanobody）NB64及胆固醇半琥珀酸酯复合物的晶体结构
配体描述：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、胆固醇半琥珀酸酯、羊驼源纳米抗体NB64，……
作者：Rudolf, A.F、Kowatsch, C、El Omari, K、Malinauskas, T、Kinnebrew, M、Ansell, T.B、Bishop, B、Pardon, E、Schwab, R.A、Qian, M、Duman, R、Covey, D.F、Steyaert, J、Wagner, A、Sansom, M.S.P、Rohatgi, R、Siebold, C
沉积日期：2019-05-27
发布日期：2019-10-02
最后修改日期：2024-11-06
实验方法：X射线衍射（分辨率1.9 Å）
引用文献：《形态发生因子音猬因子通过钳制机制抑制其受体Patched》，Nat.Chem.Biol., 15, 2019
创建时间：
2019-05-27
