Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity

Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity Descriptor: 3-(1-{2-[(3-fluoropyridinium-4-yl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)-6-methyl-8-[(3-{[(1R,3R)-3-methylpiperidinium-1-yl]methyl}-1,2-thiazol-5-yl)amino]imidazo[1,2-a]pyrazin-1-ium, Aurora kinase A Authors: Voss, M.E, Rainka, M.P, Fleming, M, Peterson, L.H, Belanger, D.B, Siddiqui, M.A, Hruza, A, Voigt, J, Basso, A.D, Gray, K. Deposit date: 2011-12-29 Release date: 2012-05-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity. Bioorg.Med.Chem.Lett., 22, 2012

具有改善的脱靶激酶选择性的咪唑并[1,2-a]吡嗪类极光激酶（Aurora kinase）抑制剂的合成与构效关系（SAR）研究
化合物描述：3-(1-{2-[(3-氟吡啶鎓-4-基)氨基]-2-氧代乙基}-1H-吡唑-4-基)-6-甲基-8-[(3-{[(1R,3R)-3-甲基哌啶鎓-1-基]甲基}-1,2-噻唑-5-基)氨基]咪唑并[1,2-a]吡嗪鎓；作用靶点：极光激酶A（Aurora kinase A）
作者：Voss, M.E、Rainka, M.P、Fleming, M、Peterson, L.H、Belanger, D.B、Siddiqui, M.A、Hruza, A、Voigt, J、Basso, A.D、Gray, K.
提交日期：2011-12-29
发布日期：2012-05-02
最后修改日期：2024-02-28
研究方法：X射线衍射法（分辨率2.66埃）
引用文献：《具有改善脱靶激酶选择性的咪唑并[1,2-a]吡嗪类极光激酶抑制剂的合成与构效关系研究》，《Bioorg.Med.Chem.Lett.》，22卷，2012年