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Haploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers

ChEBI2014-06-19 更新2026-07-21 收录

癌细胞机制

DNA复制应激

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-55041 数据链接链接失效反馈

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资源简介：

Haploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers

应用场景：

创建时间：

2014-06-19

内质网应激

癌细胞机制

Eukaryotic IRE1 mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and signals through a cytosolic kinase-endoribonuclease mo

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Wss1 promotes hydroxyurea induced replication stress tolerance

DNA复制应激

蛋白质代谢组学

Wss1 promotes replication stress tolerance Wss1 catalytic activity is essential for replication stress tolerance Histone accumulation is toxic to wss1 mutant cells during replication stress Wss1 ta

NIAID Data Ecosystem80

CD95L mRNA is toxic to cells [SmallRNA_CD95L.50hrs.Drosha_ko]

RNA干扰治疗

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>80% of a large number of tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death that is characterized by the simultaneous activation of multiple death pathways and

NIAID Data Ecosystem40

Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death [RNA-Seq]. Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death [RNA-Seq]

癌细胞机制

tRNA选择性切割

Velcrin compounds kill cancer cells expressing high levels of phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12) by inducing complex formation between these two proteins, but the mech

NIAID Data Ecosystem90

Oncogenic YAP sensitizes cells to CHK1 inhibition via CDK4/6 driven G1 acceleration

DNA复制应激

癌症靶向治疗

Replication stress is a driver of genomic instability, contributing to carcinogenesis by causing DNA damage and mutations. While YAP, the downstream co-activator of the Hippo signaling pathway, plays

NIAID Data Ecosystem60

Haploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers

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