Association between oxidative balance score and systemic immune-inflammation index: NHANES 2003–2018

As is well-known, the relationship between oxidative stress and inflammation was interdependent and interconnected, and the exact mechanism is being studied extensively. However, the research of this association was rare based on large population surveys. Notably, the Oxidative Balance Score (OBS), which could evaluate an individual’s overall antioxidant status based on 20 antioxidant and pro-oxidant components, and the Systemic immune-inflammation index (Sll), which could evaluate systemic inflammatory response, were two novel indexes. Therefore, this study adopted OBS and SII to evaluate the association between oxidative stress and inflammation using nationally representative population surveys of NHANES. To the best of our knowledge, this is the first research to investigate the relationship between OBS and SII using NHANES data. In addition, this study also conducted subgroup analysis, interaction test and non‑linear relationship analyses to explore the association further. Multiple sensitivity analyses ensured the robustness of the results.Our results illustrated that OBS was negatively associated with SII among adults. This funding emphasized that it is essential to adhere to enhancing an individual’s overall antioxidant status in diet and lifestyle and that it is helpful for the reduction of inflammation index.