NEW EMBO MEMBER’S REVIEW
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NEW EMBO MEMBER’S REVIEW
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2002-05-15
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PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells
The p85-associated phosphatidylinositol (PI) 3-kinase/Akt pathway mediates the oestradiol-induced S-phase entry and cyclin D1 promoter activity in MCF-7 cells. Experiments with Src, p85α and Akt domin
PubMed Central2001-11-01 更新510
Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication
Budding yeast Mps1p kinase has been implicated in both the duplication of microtubule-organizing centers and the spindle assembly checkpoint. Here we show that hMps1, the human homolog of yeast Mps1p,
PubMed Central2002-04-02 更新20
Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6·U5 tri-snRNP formation and pre-mRNA splicing
In each round of nuclear pre-mRNA splicing, the U4/U6·U5 tri-snRNP must be assembled from U4/U6 and U5 snRNPs, a reaction that is at present poorly understood. We have characterized a 61 kDa protein (
PubMed Central2002-03-01 更新10
STAT1 from the cell membrane to the DNA
The binding of interferons (IFNs) to their receptors leads to the phosphorylation and activation of signal transducers and activators of transcription (STATs), and their translocation from the cytopla
PubMed Central2001-05-15 更新100
F-actin-like filaments formed by plasmid segregation protein ParM
It was the general belief that DNA partitioning in prokaryotes is independent of a cytoskeletal structure, which in eukaryotic cells is indispensable for DNA segregation. Recently, however, immunofluo
PubMed Central2002-12-16 更新10



