CYP2C18
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资源简介：
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
本基因编码了细胞色素P450超家族酶的一个成员。细胞色素P450蛋白为单加氧酶，催化了许多涉及药物代谢和胆固醇、类固醇及其他脂质合成的反应。该蛋白定位于内质网，但其特异性底物尚未确定。该基因位于第10号染色体q24区的一个细胞色素P450基因簇内。此外，曾认为存在一个额外的基因CYP2C17；然而，基于CYP2C18和CYP2C19的嵌合体，现在CYP2C17被视为一个假象。对于此基因，已经发现了不同剪接转录变体，它们编码不同的同工型。[由RefSeq提供，2008年7月]
提供机构：
Rat Genome Database
