BRD4-BD1 Compound6 (methyl 4-(3,5-difluoropyridin-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-6-carboxylate)
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BRD4-BD1 Compound6 (methyl 4-(3,5-difluoropyridin-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-6-carboxylate) Descriptor: Bromodomain-containing protein 4, GLYCEROL, methyl 7-(3,5-difluoropyridin-2-yl)-2-methyl-10-[(methylsulfonyl)methyl]-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxylate Authors: Murray, J.M. Deposit date: 2020-10-21 Release date: 2021-02-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.286 Å) Cite: Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J.Med.Chem., 64, 2021
BRD4-BD1 化合物6（甲基 4-(3,5-二氟吡啶-2-基)-10-甲基-7-((甲磺酰基)甲基)-11-氧代-3,4,10,11-四氢-1H-1,4,10-三氮杂二苯并[cd,f]薁-6-羧酸酯） 描述：含溴结构域蛋白4（Bromodomain-containing protein 4）、甘油、甲基 7-(3,5-二氟吡啶-2-基)-2-甲基-10-[(甲磺酰基)甲基]-3-氧代-3,4,6,7-四氢-2H-2,4,7-三氮杂二苯并[cd,f]薁-9-羧酸酯 作者：Murray, J.M. 提交日期：2020-10-21 发布日期：2021-02-24 最后修改日期：2023-10-18 表征方法：X射线衍射（分辨率1.286 Å） 引用文献：《抗体介导的嵌合BRD4降解剂递送 第二部分：体外抗增殖活性与体内抗肿瘤功效的优化》，《药物化学杂志》（J. Med. Chem.），64卷，2021年
