Western and Heart Healthy Dietary Patterns Differentially Affect the Expression of Genes Associated with Lipid Metabolism, Interferon Signaling and Inflammation in the Jejunum of Ossabaw Pigs

Overall diet quality and statin therapy are important modulators of inflammation and CAD progression, yet their effects on jejunum is not well understood. Our objective was to examine the effects and interaction of dietary patterns and statin therapy on jejunal mucosa gene expression in the Ossabaw pig. Overall design: Thirty-two Ossabaw pigs (16 boars, 16 gilts) were randomized using a 2x2 factorial design into four groups: Hearty Healthy diet (HHD); Heart Healthy diet + atorvastatin (HHD+S); Western diet (WD, also noted as Atherigenic [ARST] below); and Western diet + atorvastatin (WD+S). Heart Healthy diet (high in unsaturated fat, unrefined grain, fruits/vegetables [HHD]) or Western diet (high in saturated fat, cholesterol, refined grain [WD]), with or without atorvastatin.

总体饮食质量与他汀类药物治疗是调节炎症和冠状动脉疾病进展的重要因素，然而，它们对空肠的影响尚未得到充分理解。本研究旨在探讨饮食模式和 he汀类药物治疗对 Ossabaw 猪空肠黏膜基因表达的影响及其相互作用。整体设计：将32头 Ossabaw 猪（公猪16头，母猪16头）采用2x2析因设计随机分为四组：丰盛健康饮食组（HHD）；丰盛健康饮食+阿托伐他汀（HHD+S）；西方饮食组（WD，以下亦称为动脉硬化原发[ARST]）；西方饮食+阿托伐他汀（WD+S）。健康心脏饮食（富含不饱和脂肪、未精炼谷物、水果/蔬菜[HHD]）或西方饮食（富含饱和脂肪、胆固醇、精炼谷物[WD]），是否添加阿托伐他汀。