Chemotherapy drugs induce different gut microbiota disorder pattern and NODs/RIP2/NF-kB signaling pathway activation that lead to different degrees of intestinal injury

The chemotherapy-induced intestinal injury limit drugs clinical use. Intestinal injury involves multiple signaling pathways and the disruption of microbiota. Our results suggest that the degree of intestinal injury caused by different drugs of the first-line colorectal chemotherapy regimen is related to the change pattern of microbiota. We found L-OHP caused the most severe change of gut microbiota, and showed considerable overlap of the microbiota changes pattern with 5-FU and CPT-11, which may provide a new basis for further elucidating the mechanism and clinical treatment of intestinal injury caused by chemotherapy.