Inflammatory molecular endotypes of nasal polyps derived from Caucasian and Japanese populations

Chronic rhinosinusitis with nasal polyps is a hallmaerk disease in the field of upper airway immunity and chronic inflammation. Diverse inflammatory patterns between nasal polyps have been described in patients that hail from disparate racial and geographic backgrounds. However, it remains unclear whether these immunologic differences in nasal polyps between racial groups are driven by unique molecular mechanisms. We interrogated the gene expression profiles of nasal polyp tissues from Western (United States) and East Asian (Japan) descent, compared to ethmoid sinus tissue controls. Overall design: Examination of the key cell types that express critical molecular genes that differentiate between nasal polyp endtypes from 2 nasal polyp samples using droplet-based single-cell RNAseq.