Crystal structure of human PHGDH complexed with Compound 1
收藏Protein Data Bank Japan2024-03-13 更新2026-03-21 收录
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Crystal structure of human PHGDH complexed with Compound 1 Descriptor: 1,2-ETHANEDIOL, 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid, D-3-phosphoglycerate dehydrogenase Authors: Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K. Deposit date: 2019-06-30 Release date: 2019-07-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg.Med.Chem.Lett., 29, 2019
创建时间：
2019-06-30
