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Deletion of a state-specific PD-1 enhancer modulates exhausted T cell fate and function. Deletion of a state-specific PD-1 enhancer modulates exhausted T cell fate and function

NIAID Data Ecosystem2026-03-13 收录

T细胞耗竭

PD-1免疫检查点调控

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA875652 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2022-09-01

T细胞耗竭

细胞重编程

The goal of this study is to determine the capacity of Tcf1 to reprogram exhausted CD8+ T cells for function restoration. Tex cells elicited by chronic infection contain a CXCR5+Tim3– subset that has

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Pd-1 High and Intermediate CD8+ T cells

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During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate ra

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Disturbed mitochondrial dynamics in CD8+ TIL reinforce epigenetic programming linked with T cell exhaustion

免疫代谢

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The metabolic challenges present in tumors attenuate the metabolic fitness and anti-tumor activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether persistent metabolic

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DEREGULATED INTRACELLULAR PATHWAYS DEFINE NOVEL MOLECULAR TARGETS FOR HBV-SPECIFIC CD8 T CELL RECONSTITUTION IN CHRONIC HEPATITIS B. DEREGULATED INTRACELLULAR PATHWAYS DEFINE NOVEL MOLECULAR TARGETS FOR HBV-SPECIFIC CD8 T CELL RECONSTITUTION IN CHRONIC HEPATITIS B

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慢性乙型肝炎免疫学

Background and aims: In chronic HBV infection elevated ROS levels by dysfunctional mitochondria can cause increased protein oxidation, proteostasis engulfment and DNA damage in exhausted virus-specifi

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RNAseq of Wild Type and Prdm1/c-Maf cDKO CD8+ Tumor infiltrating lymphocytes isolated from B16F10 melanoma

肿瘤免疫微环境

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Expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated co-inhibitory receptor expression on CD4+ T cells p

NIAID Data Ecosystem60

Deletion of a state-specific PD-1 enhancer modulates exhausted T cell fate and function. Deletion of a state-specific PD-1 enhancer modulates exhausted T cell fate and function

资源简介：

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