Design and synthesis of novel antibacterial agents against resistant bacterial infection based on cajaninstilbene acid as an antibacterial leading compound

This project will develop a broad -spectrum antibacterial novel compound by introducing different structural unit designs based on the nature product CSA. The bactericidal mechanism will study by chemoproteomics. Based on the antibacterial and anti-inflammatory effects of those compounds, we tried to explore the application of this kind compounds to chronic refractory wounds to fight infection.