AKT can phosphorylate NR4A1 (NUR77)

AKT inhibits DNA binding of NUR77 and inhibits its pro-apoptotic function (PMID 11438550). However, the relevance of AKT for NUR77 phosphorylation has recently been questioned: according to recent work, NUR77 is phosphorylated by RSK (and MSK) rather than by AKT (PMID 16223362).

AKT 抑制 NUR77 与 DNA 的结合，并抑制其促凋亡功能（PMID 11438550）。然而，AKT 对 NUR77 磷酸化的相关性近期受到质疑：根据最新研究，NUR77 的磷酸化并非由 AKT（PMID 16223362）而是由 RSK（及 MSK）所引起。