Crystal structure of Pyridoxal kinase (PdxK) from Salmonella typhimurium in complex with ADP, PL-linked to Lys233 via Schiff base in protomer A and the product (PLP) in protomer B

Crystal structure of Pyridoxal kinase (PdxK) from Salmonella typhimurium in complex with ADP, PL-linked to Lys233 via Schiff base in protomer A and the product (PLP) in protomer B Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... Authors: Deka, G, Benazir, J.F, Kalyani, J.N, Savithri, H.S, Murthy, M.R.N. Deposit date: 2018-05-14 Release date: 2019-05-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structural and functional studies on Salmonella typhimurium pyridoxal kinase: the first structural evidence for the formation of Schiff base with the substrate. Febs J., 286, 2019

鼠伤寒沙门氏菌（Salmonella typhimurium）来源的吡哆醛激酶（Pyridoxal kinase, PdxK）与腺苷二磷酸（ADP）结合的晶体结构，其中A原聚体中吡哆醛（PL）通过希夫碱（Schiff base）与Lys233相连，B原聚体中结合有反应产物磷酸吡哆醛（PLP）。配体描述：1,2-乙二醇、腺苷-5'-二磷酸、甘油…… 作者：Deka G、Benazir J.F、Kalyani J.N、Savithri H.S、Murthy M.R.N. 提交日期：2018-05-14；发布日期：2019-05-29；最后修改日期：2023-11-22。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.45埃（Å）。引用文献：《鼠伤寒沙门氏菌吡哆醛激酶的结构与功能研究：与底物形成希夫碱的首个结构证据》，《FEBS杂志》，2019年，第286卷。