Copper-Catalyzed Double C–H Alkylation of Aldehyde-Derived N,N‑Dialkylhydrazones with Polyhalomethanes: Flexible Access to 4‑Functionalized Pyrazoles
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Here, 4-functionalized pyrazoles have been made accessible in a single step from readily available aldehyde-derived N,N-dialkyl hydrazones and functionalized polyhalomethane derivatives. The process is believed to follow copper-catalyzed cascade C(sp2)–H haloalkylation/C(sp3)–H cyclization/aromatization reaction sequences.
创建时间：
2016-10-03
