C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin

C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin Descriptor: (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Hibbs, R.E, Gouaux, E. Deposit date: 2011-04-12 Release date: 2011-05-25 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature, 474, 2011

秀丽隐杆线虫谷氨酸门控氯离子通道（C. elegans glutamate-gated chloride channel, GluCl）与抗原结合片段（Fab）、伊维菌素（ivermectin）及印防己毒素（picrotoxin）的复合物
描述符：(1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-羟基-8b-甲基-9-(丙-1-烯-2-基)六氢-3,6-桥亚甲基-1,5,7-三氧杂环戊烷[ij]环丙烯[a]薁-4,8(3H)-二酮，(2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-丁-2-基]-20,20b-二羟基-5',6,8,19-四甲基-17-氧代-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-十四氢-2H,7H-螺[11,15-桥亚甲基呋喃并[4,3,2-pq][2,6]苯并二氧杂环十八烷-13,2'-吡喃]-7-基 2,6-二脱氧-4-O-(2,6-二脱氧-3-O-甲基-α-L-阿拉伯己吡喃糖基)-3-O-甲基-α-L-阿拉伯己吡喃糖苷，2-乙酰氨基-2-脱氧-β-D-葡萄糖吡喃糖……
作者：希布斯（Hibbs, R.E）、古奥（Gouaux, E.）
入库日期：2011-04-12
发布日期：2011-05-25
最后修改日期：2024-10-30
实验方法：X射线衍射（分辨率3.4埃）
引用文献：《阴离子选择性半胱氨酸环受体的激活与渗透原理》，《自然》（*Nature*），第474卷，2011年