Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase

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Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Descriptor: Glycogen phosphorylase, muscle form, N-(trifluoroacetyl)-beta-D-glucopyranosylamine, ... Authors: Anagnostou, E, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Hadjiloi, T, Tiraidis, C, Zographos, S.E, Gyorgydeak, Z, Somsak, L, Docsa, T, Gergely, P, Kolisis, F.N, Oikonomakos, N.G. Deposit date: 2004-12-31 Release date: 2005-12-13 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-d-glucopyranosylamine and N-trifluoroacetyl-beta-d-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Bioorg.Med.Chem., 14, 2006

针对两种生物电子等排类似物（bioisosteric analogues）的晶体学研究：N-乙酰基-β-D-吡喃葡萄糖基胺（N-acetyl-beta-D-glucopyranosylamine）与N-三氟乙酰基-β-D-吡喃葡萄糖基胺（N-trifluoroacetyl-beta-D-glucopyranosylamine），二者均为强效的肌肉糖原磷酸化酶抑制剂。描述符：肌肉型糖原磷酸化酶（Glycogen phosphorylase, muscle form）、N-(三氟乙酰基)-β-D-吡喃葡萄糖基胺（N-(trifluoroacetyl)-beta-D-glucopyranosylamine）等作者：Anagnostou, E、Kosmopoulou, M.N、Chrysina, E.D、Leonidas, D.D、Hadjiloi, T、Tiraidis, C、Zographos, S.E、Gyorgydeak, Z、Somsak, L、Docsa, T、Gergely, P、Kolisis, F.N、Oikonomakos, N.G 提交日期：2004-12-31 发布日期：2005-12-13 最后修改日期：2023-10-25 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.8埃（1.8 Å）引用文献：针对两种生物电子等排类似物N-乙酰基-β-D-吡喃葡萄糖基胺与N-三氟乙酰基-β-D-吡喃葡萄糖基胺的晶体学研究：肌肉糖原磷酸化酶强效抑制剂，《Bioorg.Med.Chem.》，第14卷，2006年

创建时间：

2004-12-31