Immune microenvironment and molecular mechanism of oral lichen planus [Spatial transcriptomics]

Oral lichen planus (OLP) is a poorly understood chronic inflammatory mucocutaneous disease and is associated with many systemic diseases, which may lead to the erosion of oral mucosa and bring physical and psychological disorders to patients. However, the pathogenesis and immune microenvironment of OLP with different clinical subtypes are unclear. therefore, this study utilized single cell RNA-sequencing and spatial transcriptomics to explore the immune microenvironment and molecular mechanism of oral lichen planus with different clinical subtypes. Moreover, this study established a clinical cohort of OLP with 1-year follow-up and obtained the clinical information and bulk RNA-seq files to further confirm the above results. Overall design: Comparative spatial heterogeneity analysis of spatial transcriptomics for non-erosive OLP (NEOLP) and erosive OLP (EOLP).