Metal-Free Three-Component Domino Approach to Phosphonylated Triazolines and Triazoles
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https://figshare.com/articles/dataset/Metal_Free_Three_Component_Domino_Approach_to_Phosphonylated_Triazolines_and_Triazoles/2087560
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资源简介：
An efficient, three-component domino
reaction between aldehydes,
amines, and the Bestmann–Ohira reagent is reported that enables
a general, mild, and straightforward access to 1,4,5-trisubstituted
1,2,3-triazolines and triazoles. The reaction proceeds through a domino-condensation/1,3-dipolar
cycloaddition sequence to afford the triazoline derivatives with excellent
diastereoselectivity. Moreover, when both amine and aldehyde employed
for this reaction are aromatic, a spontaneous oxidation afforded 1,4,5-trisubstituted
triazoles in moderate yields.
创建时间：
2016-02-12
