Nucleotide-free Cryo-EM Structure of E.coli LptB2FG Transporter

Nucleotide-free Cryo-EM Structure of E.coli LptB2FG Transporter Descriptor: (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-5-[(2~{S},3~{S},4~{R},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{R},5~{S},6~{R})-6-[(1~{S})-2-[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-1-oxidanyl-ethyl]-3,4-bis(oxidanyl)-5-phosphonooxy-oxan-2-yl]oxy-3-oxidanyl-5-phosphonooxy-oxan-2-yl]oxy-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Lipopolysaccharide export system ATP-binding protein LptB, Lipopolysaccharide export system permease protein LptF, ... Authors: Orlando, B.J, Li, Y, Liao, M. Deposit date: 2018-09-18 Release date: 2019-04-03 Last modified: 2025-05-14 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature, 567, 2019大肠杆菌LptB2FG转运蛋白无核苷酸冷冻电镜（Cryo-EM）结构 数据集描述：(2R,4R,5R,6R)-6-[(1R)-1,2-二羟基乙基]-2-[(2R,4R,5R,6R)-6-[(1R)-1,2-二羟基乙基]-5-[(2S,3S,4R,5R,6R)-6-[(1S)-1,2-二羟基乙基]-4-[(2R,3S,4R,5S,6R)-6-[(1S)-2-[(2S,3S,4S,5S,6R)-6-[(1S)-1,2-二羟基乙基]-3,4,5-三羟基氧杂环己-2-基]氧基-1-羟基乙基]-3,4-二羟基-5-膦酰氧基氧杂环己-2-基]氧基-3-羟基-5-膦酰氧基氧杂环己-2-基]氧基-2-羧基-2-[[(2R,3S,4R,5R,6R)-5-[[(3R)-3-十二酰氧基十四酰基]氨基]-6-[[(2R,3S,4R,5R,6R)-3-羟基-5-[[(3R)-3-羟基十四酰基]氨基]-4-[(3R)-3-羟基十四酰基]氧基-6-膦酰氧基氧杂环己-2-基]甲氧基]-3-膦酰氧基-4-[(3R)-3-十四酰氧基十四酰基]氧基氧杂环己-2-基]甲氧基]氧杂环己-4-基]氧基-4,5-二羟基氧杂环己烷-2-羧酸、脂多糖输出系统ATP结合蛋白LptB、脂多糖输出系统通透酶蛋白LptF等 作者：Orlando, B.J、Li, Y、Liao, M. 提交日期：2018-09-18 发布日期：2019-04-03 最后修改日期：2025-05-14 实验方法：电子显微镜（分辨率4 Å） 引用文献：《LptB2FGC复合物提取脂多糖的结构基础》，《自然》（Nature），567卷，2019年