Table1_Cord blood fatty acid binding protein 4 and lipids in infants born small- or large-for-gestational-age.pdf

AimAdverse (poor or excessive) fetal growth “programs” an elevated risk of type 2 diabetes. Fatty acid binding protein 4 (FABP4) has been implicated in regulating insulin sensitivity and lipid metabolism relevant to fetal growth. We sought to determine whether FABP4 is associated with poor or excessive fetal growth and fetal lipids.MethodsIn a nested case-control study in the Shanghai Birth Cohort including 60 trios of small-for-gestational-age (SGA, an indicator of poor fetal growth), large-for-gestational-age (LGA, an indicator of excessive fetal growth) and optimal-for-gestational-age (OGA, control) infants, we measured cord blood concentrations of FABP4 and lipids [high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterols, triglycerides (TG)].ResultsAdjusting for maternal and neonatal characteristics, higher cord blood FABP4 concentrations were associated with a lower odds of SGA [OR = 0.29 (0.11–0.77) per log unit increment in FABP4, P = 0.01], but were not associated with LGA (P = 0.46). Cord blood FABP4 was positively correlated with both LDL (r = 0.29, P = 0.025) and HDL (r = 0.33, P = 0.01) in LGA infants only.ConclusionFABP4 was inversely associated with the risk of SGA. The study is the first to demonstrate LGA-specific positive correlations of cord blood FABP4 with HDL and LDL cholesterols, suggesting a role of FABP4 in fetal lipid metabolism in subjects with excessive fetal growth.

胎儿生长发育（不良或过度）的“程序”增加了2型糖尿病的风险。脂肪酸结合蛋白4（FABP4）被证实与调节胰岛素敏感性和与胎儿生长相关的脂质代谢有关。本研究旨在探究FABP4是否与不良或过度胎儿生长及胎儿脂质相关。方法：在上海出生队列中，我们进行了一项嵌套病例对照研究，包括60组小样儿（SGA，不良胎儿生长的指标）、大样儿（LGA，过度胎儿生长的指标）和适宜胎儿生长的对照组（OGA）婴儿。我们测量了脐带血中FABP4和脂质[高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇、甘油三酯（TG）]的浓度。结果：调整母亲和新生儿特征后，较高的脐带血FABP4浓度与SGA的较低发生几率相关[OR = 0.29（FABP4每增加一个对数单位，OR = 0.29，95%置信区间为0.11–0.77，P = 0.01）]，但与LGA无关（P = 0.46）。在LGA婴儿中，脐带血FABP4与LDL（r = 0.29，P = 0.025）和HDL（r = 0.33，P = 0.01）呈正相关。结论：FABP4与SGA的风险呈负相关。本研究首次证明了LGA特异性地脐带血FABP4与HDL和LDL胆固醇的正相关关系，表明FABP4在过度胎儿生长个体中的胎儿脂质代谢中发挥作用。