Gut microbiota metabolite IPA released by Akk ameliorates DIC by regulating PPARα-dependent mitochondrial biogenesis
收藏Mendeley Data2026-04-09 收录
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AKK supplementation increased serum levels of the tryptophan metabolite indole-3-propionic acid (IPA), which binds to the cardiac aryl hydrocarbon receptor (AhR), leading to the activation of the PPARα/PGC1α signaling pathway. These findings highlight the potential of AKK as a probiotic in mitigating DIC.
