Tandem Thien- and Benzannulations of α‑Alkenoyl-α-alkynyl Ketene Dithioacetals with Cyanoacetates: Synthesis of Functionalized Benzo[b]thiophenes

A novel domino annulation strategy for the construction of benzo­[b]­thiophenes has been developed. In the presence of Cs2CO3 and Ag2CO3, a wide range of α-alkenoyl-α-alkynyl ketene dithioacetals readily react with cyanoacetates in CH3CN at 110 °C under N2 to afford multisubstituted benzo­[b]­thiophenes efficiently via tandem thien- and benzannulations. A plausible mechanism is also proposed.