2000HIV bulk transcriptomics after stimulation with Imiquimod (TLR7 agonist)

This data repository contains the bulk transcriptomics (gene expression) data of the 2000HIV study of PBMCs of 70 people living with HIV and 43 healthy controls after stimulation with the TLR7 agonist Imiquimod.
The 2000HIV study is a prospective longitudinal cohort study of people living with HIV (PLHIV) on cART. It aims to discover new biological pathways and identify biomarkers that play a role in persistent inflammation, accelerated ageing, non-AIDS co-morbidities, extreme HIV-related clinical phenotypes (Elite controllers, immunological non-responders, and rapid progressors) and the HIV viral reservoir size and composition. Extensive clinical data and measurements were registered, multi-omics data were generated, and the latent viral reservoir size and composition were assessed in this cohort. In addition, a substudy called 2000HIV-TRAINED was conducted to include people living with HIV and their first-degree HIV-negative family members. The healthy controls included in this transcriptomics data were included for the 2000HIV-TRAINED substudy.