Hyperjapones A–E, Terpenoid Polymethylated Acylphloroglucinols from <i>Hypericum japonicum</i>
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Hyperjapones A–E (1–5), novel terpenoid polymethylated acylphloroglucinols (TPAPs) with unusual architectures, were characterized from Hypericum japonicum. Their structures and absolute configurations were determined by comprehensive spectroscopic data and X-ray diffractions. Compound 1 was obtained as a racemic mixture and was separated by a column coated with cellulose tris(4-methylbenzoate) after attempts with various chiral materials. Compounds 1, 2, and 4 exhibited moderate antitumor activities in vitro.
创建时间:
2016-04-11



