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Subtherapeutic linezolid treatment of T. pallidum

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https://www.ncbi.nlm.nih.gov/sra/SRP400325
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T. pallidum strain SS14 was co-cultured with rabbit SfEp1 cells and treated with a subtherapeutic dose of linezolid. Treponemes were harvested every week, subjected to hybrid capture/whole genome sequencing, and consensus sequence and minor alleles inspected for resistance mutation accumulation.
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2022-11-28
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