Crystal structure of Plasmodium vivax hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine

Crystal structure of Plasmodium vivax hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine Descriptor: Hypoxanthine phosphoribosyltransferase, MAGNESIUM ION, [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-y l]-3-oxidanylidene-propyl]phosphonic acid Authors: Guddat, L.W, Keough, D.T, Rejman, D. Deposit date: 2017-11-18 Release date: 2017-12-13 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.856 Å) Cite: Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics. ACS Chem. Biol., 13, 2018

间日疟原虫（Plasmodium vivax）次黄嘌呤鸟嘌呤磷酸核糖转移酶（hypoxanthine guanine phosphoribosyltransferase）与[3R,4R]-4-鸟嘌呤-9-基-3-((S)-2-羟基-2-膦酰乙基)氧基-1-N-(膦酰丙酰基)吡咯烷形成的复合物的晶体结构。描述符：次黄嘌呤磷酸核糖转移酶（Hypoxanthine phosphoribosyltransferase）、镁离子（MAGNESIUM ION）、[3-[(3R,4R)-3-(2-氨基-6-氧代-1H-嘌呤-9-基)-4-[(2S)-2-羟基-2-膦酰乙氧基]吡咯烷-1-基]-3-氧代丙基]膦酸。作者：Guddat, L.W.、Keough, D.T.、Rejman, D.。存放日期：2017-11-18；发布日期：2017-12-13；最后修改日期：2024-03-13。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.856埃（Å）。引用文献：《间日疟原虫次黄嘌呤-鸟嘌呤磷酸核糖转移酶抑制剂作为潜在抗疟治疗药物的设计》，发表于ACS Chem. Biol.，第13卷，2018年。