Crystal Structure of small molecule KN2H covalently bound to K-Ras(G12D)

Crystal Structure of small molecule KN2H covalently bound to K-Ras(G12D) Descriptor: 1,2-ETHANEDIOL, 1-[(1~{S},5~{R})-3-[7-(8-ethynyl-7-fluoranyl-3-oxidanyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]ethanone, GTPase KRas, ... Authors: Zhou, L, Zhang, R, Shuai, T.B. Deposit date: 2023-09-08 Release date: 2024-09-11 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Crystal Structure of small molecule KN2H covalently bound to K-Ras(G12D) To Be Published与K-Ras(G12D)共价结合的小分子KN2H晶体结构 描述：1,2-乙二醇（1,2-ETHANEDIOL）、1-[(1S,5R)-3-[7-(8-乙炔基-7-氟-3-羟基-萘-1-基)-8-氟-2-[[(2R,8S)-2-氟-1,2,3,5,6,7-六氢吡咯里嗪-8-基]甲氧基]吡啶并[4,3-d]嘧啶-4-基]-3,8-二氮杂双环[3.2.1]辛烷-8-基]乙酮、GTP酶KRas（GTPase KRas）…… 作者：Zhou, L、Zhang, R、Shuai, T.B. 提交日期：2023-09-08 发布日期：2024-09-11 最后修改日期：2024-10-09 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.72 Å 引用信息：《与K-Ras(G12D)共价结合的小分子KN2H晶体结构》，待发表