Vibrio anguillarum promotes CypA expression to activate the PI3K-AKt/MAPK signaling pathway enhancing Edwardsiella piscicida to invade hosts

In aquatic environments, co-infections caused by multiple pathogens is widely distributed to complicating the field control of infectious fish diseases by the interactions between pathogens and pathogen-hosts. Co-infection have altered the fish susceptibility and epidemiology towards a wide range of pathogens. Deep research into the co-infection mechanisms will provide new strategies curing or alleviating fish diseases. Increasing evidence have been emerged that Cyclophilin A is the crucial factor mediating successful infectious diseases and plays important roles in the disease development. However, how this chemical is working on the aquatic co-infections is yet unclear Edwardsi lla piscicida and Vibrio anguillarum cause hemorrhagic septicemia in fis and lead to severe co-infections during turbot farming with huge economical l sses.