Annotation of the phages in the community and analysis of mutations detected during the evolution experiment.

CDS: coding sequence, RBP: receptor-binding protein. S4A. Annotation of the ancestral phages of the initial phage community. S4B. Variant calling analyses of the evolved phage communities. S4C. Variable positions of the whole genome alignment of parental and evolved phages. -: deletion. S4D. Results of the Branch-Site Unrestricted Statistical Test for Episodic Diversification (BUSTED) for CDSs where the tested dN/dS ratio was > 1. dN/dS: ratio of non-synonymous to synonymous substitutions, CoV: Coefficient of variation.
(XLSX)