Estimated means of the log-transformed data at each visit, changes within group compared to baseline, and mean differences of change between groups compared to baseline.

Data are log-transformed and presented as mean (95% confidence interval) or mean difference (95% confidence interval for difference).CML, Nε mn-(Carboxymethyl) lysine; CEL, Nε-(Carboxyethyl) lysine; MG-H1, 5-hydro-5-methylimidazolone; s-ICAM, serum inter-cellular adhesion molecule-1; s-VCAM, serum vascular cell adhesion molecule-1; Hs-CRP, high sensitive C-reactive protein; SAA, serum amyloid A; MPO, myeloperoxidase.