Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor

Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor Descriptor: 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide, GLYCEROL, N-lysine methyltransferase SMYD2, ... Authors: Nguyen, H, Allali-Hassani, A, Antonysamy, S, Chang, S, Chen, L.H, Curtis, C, Emtage, S, Fan, L, Gheyi, T, Li, F, Liu, S, Martin, J.R, Mendel, D, Olsen, J.B, Pelletier, L, Shatseva, T, Wu, S, Zhang, F.F, Arrowsmith, C.H, Brown, P.J, Campbell, R.M, Garcia, B.A, Barsyte-Lovejoy, D, Mader, M, Vedadi, M. Deposit date: 2014-11-04 Release date: 2015-04-08 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. J.Biol.Chem., 290, 2015

与细胞活性、强效且选择性抑制剂LLY-507结合的蛋白质赖氨酸甲基转移酶（Protein Lysine Methyltransferase）SMYD2的晶体结构
样品组成描述：5-氰基-2'-{4-[2-(3-甲基-1H-吲哚-1-基)乙基]哌嗪-1-基}-N-[3-(吡咯烷-1-基)丙基]联苯-3-甲酰胺、甘油、N-赖氨酸甲基转移酶（N-lysine methyltransferase）SMYD2等
作者：Nguyen, H、Allali-Hassani, A、Antonysamy, S、Chang, S、Chen, L.H、Curtis, C、Emtage, S、Fan, L、Gheyi, T、Li, F、Liu, S、Martin, J.R、Mendel, D、Olsen, J.B、Pelletier, L、Shatseva, T、Wu, S、Zhang, F.F、Arrowsmith, C.H、Brown, P.J、Campbell, R.M、Garcia, B.A、Barsyte-Lovejoy, D、Mader, M、Vedadi, M
沉积日期：2014-11-04
发布日期：2015-04-08
最后修改日期：2023-12-27
检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.63埃（Å）
引用文献：《蛋白质赖氨酸甲基转移酶SMYD2的细胞活性、强效选择性抑制剂LLY-507》，《生物化学杂志》（J. Biol. Chem.），第290卷，2015年