T regulatory (Treg) cells maintain immunological tolerance and their depletion in humans and mice results in autoimmune disease. The development of Treg cells in the thymus, their differentiation into
Tumor necrosis factor receptor 2 (TNFR2), a membrane-bound tumor necrosis factor receptor expressed by regulatory T cells (Tregs), participates in Treg proliferation. Although a specific TNFR2 pathway
FoxP3 binding sites in Treg cells expressing WT or A384T mutant FoxP3 were examined. Overall design: Chromatin was prepared from FoxP3+ Treg cells from FoxP3WT and FoxP3A384T mice, immunoprecipitated
We found miR-125a was a key regulator that stabilizes the commitment and immunoregulatory capacity of Treg cells.To gain insights into the general functional features of miR-125a-deficient Treg cells,
