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Reprogramming by de-bookmarking somatic transcriptional program via targeting the BET bromodomains

ChEBI2016-08-22 更新2026-07-12 收录

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细胞重编程

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-75364 数据链接链接失效反馈

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Reprogramming by de-bookmarking somatic transcriptional program via targeting the BET bromodomains

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创建时间：

2016-08-22

朊病毒与细胞衰老

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Organisms often commit to one of two strategies: living fast and dying young or living slow and dying old. In fluctuating environments, however, switching between these two strategies could be advanta

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Addressing the specific roles of histone modifications in transcriptional repression [RNA-seq]

组蛋白修饰转录抑制

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Our understanding of epigenetic processes is based on the hypothesis that individual posttranslational modifications of DNA and histones, or combinations thereof, function to direct unique downstream

NIAID Data Ecosystem00

Mitochondrial Fission 1 (FIS1) knockdown effect on the H3K27Ac status of leukemia cell line MOLM-13 cells. Mitochondrial Fission 1 (FIS1) knockdown effect on the H3K27Ac status of leukemia cell line MOLM-13 cells

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肾病与白血病基因功能研究

To examine if loss of FIS1 would alter the H3K27Ac status of leukemic cells, we used shRNA to knock down the expression of FIS1 in leukemic cell line MOLM-13 cells and performed H3K27Ac CHIP-seq to ch

NIAID Data Ecosystem00

DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation [RNA-seq]

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甲基化反应机制

DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

NIAID Data Ecosystem00

An epigenetic switch in vascular phenotype augments anti-tumor immunity [bulkRNA-seq]

肿瘤免疫微环境

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The abnormal tumor vasculature can present a barrier to the infiltration of anti-tumor immune cells, which impairs immune surveillance and response to immunotherapy. Here, we show that targeting the e

NIAID Data Ecosystem00

Reprogramming by de-bookmarking somatic transcriptional program via targeting the BET bromodomains

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