Linear regression analyses to examine the relationship of each parameter with age and the impact of HIV infection on this relationship.

Bivariable regression analyses shown are performed on combined HIV negative and HIV positive participants with age as an outcome, adjusting for HIV status. An interaction model whereby each group had its own slope for the parameter value over age (stratified by HIV status) was compared to a model of common slope (non-stratified model) using the likelihood ratio test and the model of best fit is shown.ap value that the slope of the line is non-zero.bp value that the intercept of the line is different for HIV positive and HIV negative.cOne outlier was excluded from this analysis.dThe model with the best fit for CXCL10 was stratified by HIV status and as such the slopes for HIV negative and HIV positive groups are different and are shown separately.eThis term describes the difference in slope between the HIV positive and HIV negative models. The p value indicates that the slopes are significantly different.Note. p values Abbreviations: CI, confidence interval; LPS, lipopolysaccharide.