Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 12

Crystal structure of human MAT2a bound to S-Adenosylmethionine and Compound 12 Descriptor: 4-[4-[bis(fluoranyl)methoxy]phenyl]-3-cyclopropyl-2~{H}-pyrazolo[4,3-b]pyridin-5-one, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 Authors: Schimpl, M. Deposit date: 2023-08-30 Release date: 2024-03-20 Last modified: 2024-04-10 Method: X-RAY DIFFRACTION (1.12 Å) Cite: Development of a Series of Pyrrolopyridone MAT2A Inhibitors. J.Med.Chem., 67, 2024人源MAT2a与S-腺苷甲硫氨酸（S-Adenosylmethionine）及化合物12结合的晶体结构 描述符：4-[4-(二氟甲氧基)苯基]-3-环丙基-2H-吡唑并[4,3-b]吡啶-5-酮、S-腺苷甲硫氨酸、S-腺苷甲硫氨酸合酶2型同工酶 作者：Schimpl, M. 入库日期：2023-08-30 发布日期：2024-03-20 最后更新：2024-04-10 实验方法：X射线衍射（分辨率1.12 Å） 引用文献：《吡咯并吡啶酮类MAT2A抑制剂系列的开发》，《药物化学杂志》（J. Med. Chem.），第67卷，2024年